PFS has altered neurohormone levels and 5AR2 methylation alterations (studies). PAS might too.

BD_Acc

New member
Mar 11, 2018
9
11
3
#1
Altered methylation pattern of the SRD5A2 gene in cerebrospinal fluid of post-finasteride patients: a pilot study.
https://www.ncbi.nlm.nih.gov/m/pubmed/31272082/

Neuroactive steroid levels and psychiatric and andrological features in post-finasteride patients. https://www.ncbi.nlm.nih.gov/m/pubmed/28408350/?i=2&from=/31272082/related

These studies find big drops in CSF levels of oestradiol and DHT in CSF (together responsible for libido/sexual function) and also dihyrdoprogesterone (not sure what this does).
The top one also finds altered methylation of the 5AR2 gene in half of the PFS patients.

I don't know where we would have to send CSF samples to have these tests done. Figuring that out is the next step.
 
Mar 20, 2019
24
12
3
#2
Dihydroprogesterone is also a major precursor to allopregnenolone which probably accounts for the lowered mood and suicides associated with 5 alpha reducatse inhibitors such as finasteride and accutane.
 
Mar 11, 2018
9
11
3
#3
Have been thinking more about this. If you had a tube running through your skull into the CSF you could run a slow infusion of DHT, E2 and whatever else is affected directly into your CSF. This could be a viable treatment option if receptor numbers are still fine and they are responsive.

Definitely seems worth getting CSF testing done.